Tendinopathy: Causes, Risks, and Medications That Affect Tendon Health

When your tendon hurts, it’s not just a strain—it could be tendinopathy, a degenerative condition where tendons break down due to overuse, aging, or medication side effects. Also known as tendonitis or tendinosis, it’s not always inflammation—it’s often structural damage that doesn’t heal right. This isn’t just a runner’s problem. Anyone who lifts, types, or even walks a lot can develop it. And here’s the thing: some common meds might be making it worse without you even knowing.

Take bempedoic acid, a cholesterol-lowering drug used when statins don’t work. Also sold as Nexletol, it’s effective—but the FDA warns it can raise the risk of tendon rupture. That’s not a rare side effect. Studies show it can weaken tendons, especially the Achilles, in people over 50 or those already active. It’s not just this drug, either. Fluoroquinolone antibiotics like ciprofloxacin, corticosteroids injected near tendons, and even some antidepressants have been linked to tendon damage. These aren’t just side effects listed in fine print—they’re real, measurable risks that show up in clinical data.

If you’re on any of these meds and notice persistent pain, stiffness, or a sudden pop in your shoulder, heel, or wrist, don’t wait. Tendinopathy starts slow. By the time it hurts badly, the damage is often advanced. The good news? Catching it early means you can adjust your activity, switch meds, or start physical therapy before a rupture happens. You don’t need to stop moving—just move smarter. And if you’re prescribed a new drug, ask: Could this affect my tendons? It’s a simple question that could save you months of rehab.

Below, you’ll find real-world insights from people who’ve dealt with tendon issues linked to medications, what doctors are saying now, and how to spot the warning signs before it’s too late. No fluff. Just what you need to protect your body while managing your health.